Wegovy (oral 25mg) vs CagriSema
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Side-by-side comparison based on OASIS-4 and REDEFINE-1 phase 3 trial data plus May 2026 pricing.
Wegovy (oral 25mg)
semaglutide (tablet)
Peak weight loss13.6%
TrialOASIS-4
Administrationoral
FDA statusweight-loss
List price$1,349/mo
CagriSema
Higher efficacycagrilintide + semaglutide
Peak weight loss20.4%
TrialREDEFINE-1
Administrationinjection
FDA statuspending
List price$1,499/mo
Weight loss comparison (220 lbs starting weight)
% of body weight lost over 18 months, modeled from phase 3 trial data
Monthly cost by payment channel
| Channel | Wegovy (oral 25mg) | CagriSema | Difference |
|---|---|---|---|
| Covered by insurance ($25–150 copay) | $63 | $88 | $25 (Wegovy (oral 25mg) cheaper) |
| Manufacturer self-pay (LillyDirect / NovoCare) | $149 | $599 | $450 (Wegovy (oral 25mg) cheaper) |
| Telehealth: brand name (Hims, Ro, Found) | $449 | - | - |
| Cash retail (full list price) | $1,349 | $1,499 | $150 (Wegovy (oral 25mg) cheaper) |
Wegovy (oral 25mg) pros and cons
Pros
- ✓ No injections - daily oral pill
- ✓ Same molecule as Wegovy injection
- ✓ 13.6% average weight loss in OASIS-4
- ✓ Easier to skip a dose without long-acting tail
Cons
- ✗ Strict fasting requirements before/after dose
- ✗ Slightly lower weight loss than injection (13.6% vs 14.9%)
- ✗ Daily dosing may hurt adherence vs weekly injection
- ✗ Newer drug - fewer real-world data points
CagriSema pros and cons
Pros
- ✓ Highest efficacy of any pending GLP-1 (20.4% in REDEFINE-1)
- ✓ Dual mechanism (amylin + GLP-1) targets satiety differently
- ✓ Once-weekly injection like Wegovy
Cons
- ✗ Pending FDA approval (expected 2026)
- ✗ Combination therapy may carry premium pricing
- ✗ Limited long-term real-world data
Common side effects
Wegovy (oral 25mg)
- • Nausea
- • Diarrhea
- • Constipation
- • Vomiting
CagriSema
- • Nausea
- • Diarrhea
- • Vomiting
- • Constipation
- • Decreased appetite
Which should you choose: Wegovy (oral 25mg) or CagriSema?
Choose Wegovy (oral 25mg) if: you prefer a daily pill over a weekly injection; cash-pay cost matters most to you; you want a drug FDA-approved specifically for weight loss.
Choose CagriSema if: you want maximum weight loss (20.4% vs 13.6%); you prefer a weekly injection over a daily pill.
Final decisions should always be made with a licensed prescriber. This is educational content only.
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Where to actually buy Wegovy (oral 25mg) or CagriSema (and the alternatives)
Manufacturer direct prices (LillyDirect, NovoCare) are usually cheapest. Updated May 2026.
| Drug | Insurance | Mfr direct | Telehealth (brand) | Telehealth (compd) | Cash retail | Get it |
|---|---|---|---|---|---|---|
| Wegovy 14.9% weight loss | $63 | $349 | $329 | $249 cheapest | $1,349 | Get → |
| Ozempic 11.6% weight loss | $63 | - | $399 | $199 cheapest | $998 | Get → |
| Wegovy (oral 25mg) 13.6% weight loss | $63 | $149 cheapest | $449 | - | $1,349 | Get → |
| Zepbound 22.5% weight loss | $88 | $299 cheapest | $499 | $299 cheapest | $1,059 | Get → |
| Mounjaro 20.9% weight loss | $88 | - | $499 | $299 cheapest | $1,069 | Get → |
| Saxenda 8.4% weight loss | $63 | - | $399 cheapest | - | $1,349 | Get → |
| Foundayo (orforglipron) 14.7% weight loss | $63 | $149 cheapest | - | - | $1,099 | Get → |
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Medical disclaimer: This calculator provides estimates only based on phase 3 clinical trial data and publicly listed prices. It is not medical advice. Real-world weight loss varies significantly. Consult a licensed healthcare provider before starting any medication.
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