Foundayo (orforglipron) vs CagriSema
NY State Bar #5361159 · Hawaii State Bar · Founder, GLP1Cost.org
Side-by-side comparison based on ATTAIN-1 and REDEFINE-1 phase 3 trial data plus May 2026 pricing.
Foundayo (orforglipron)
orforglipron (tablet)
Peak weight loss14.7%
TrialATTAIN-1
Administrationoral
FDA statusweight-loss
List price$1,099/mo
CagriSema
Higher efficacycagrilintide + semaglutide
Peak weight loss20.4%
TrialREDEFINE-1
Administrationinjection
FDA statuspending
List price$1,499/mo
Weight loss comparison (220 lbs starting weight)
% of body weight lost over 18 months, modeled from phase 3 trial data
Monthly cost by payment channel
| Channel | Foundayo (orforglipron) | CagriSema | Difference |
|---|---|---|---|
| Covered by insurance ($25–150 copay) | $63 | $88 | $25 (Foundayo (orforglipron) cheaper) |
| Manufacturer self-pay (LillyDirect / NovoCare) | $149 | $599 | $450 (Foundayo (orforglipron) cheaper) |
| Telehealth: brand name (Hims, Ro, Found) | - | - | - |
| Cash retail (full list price) | $1,099 | $1,499 | $400 (Foundayo (orforglipron) cheaper) |
Foundayo (orforglipron) pros and cons
Pros
- ✓ Daily pill with NO food or water restrictions (advantage over oral Wegovy 25 mg)
- ✓ Non-peptide small molecule - easier manufacturing and scaling
- ✓ 14.7% average weight loss in ATTAIN-1
- ✓ LillyDirect self-pay starts at $149/mo for the lowest dose
- ✓ Medicare Part D coverage as low as $50/mo beginning July 1, 2026
Cons
- ✗ New molecule (April 2026 approval) - limited real-world safety data outside trials
- ✗ Daily adherence required
- ✗ Higher doses (14.5/17.2 mg) price up to $349/mo out of refill window
CagriSema pros and cons
Pros
- ✓ Highest efficacy of any pending GLP-1 (20.4% in REDEFINE-1)
- ✓ Dual mechanism (amylin + GLP-1) targets satiety differently
- ✓ Once-weekly injection like Wegovy
Cons
- ✗ Pending FDA approval (expected 2026)
- ✗ Combination therapy may carry premium pricing
- ✗ Limited long-term real-world data
Common side effects
Foundayo (orforglipron)
- • Nausea
- • Diarrhea
- • Vomiting
- • Constipation
CagriSema
- • Nausea
- • Diarrhea
- • Vomiting
- • Constipation
- • Decreased appetite
Which should you choose: Foundayo (orforglipron) or CagriSema?
Choose Foundayo (orforglipron) if: you prefer a daily pill over a weekly injection; cash-pay cost matters most to you; you want a drug FDA-approved specifically for weight loss.
Choose CagriSema if: you want maximum weight loss (20.4% vs 14.7%); you prefer a weekly injection over a daily pill.
Final decisions should always be made with a licensed prescriber. This is educational content only.
Affiliate disclosure: This page contains affiliate links. We may earn a commission if you click through and complete a qualifying action. Your price does not change. Affiliate revenue does not influence our pricing data or rankings - full disclosure.
Where to actually buy Foundayo (orforglipron) or CagriSema (and the alternatives)
Manufacturer direct prices (LillyDirect, NovoCare) are usually cheapest. Updated May 2026.
| Drug | Insurance | Mfr direct | Telehealth (brand) | Telehealth (compd) | Cash retail | Get it |
|---|---|---|---|---|---|---|
| Wegovy 14.9% weight loss | $63 | $349 | $329 | $249 cheapest | $1,349 | Get → |
| Ozempic 11.6% weight loss | $63 | - | $399 | $199 cheapest | $998 | Get → |
| Wegovy (oral 25mg) 13.6% weight loss | $63 | $149 cheapest | $449 | - | $1,349 | Get → |
| Zepbound 22.5% weight loss | $88 | $299 cheapest | $499 | $299 cheapest | $1,059 | Get → |
| Mounjaro 20.9% weight loss | $88 | - | $499 | $299 cheapest | $1,069 | Get → |
| Saxenda 8.4% weight loss | $63 | - | $399 cheapest | - | $1,349 | Get → |
| Foundayo (orforglipron) 14.7% weight loss | $63 | $149 cheapest | - | - | $1,099 | Get → |
Some links are affiliate. We earn a commission at no cost to you. We never recommend a product based on commission. Disclaimer.
Medical disclaimer: This calculator provides estimates only based on phase 3 clinical trial data and publicly listed prices. It is not medical advice. Real-world weight loss varies significantly. Consult a licensed healthcare provider before starting any medication.
More comparisons
Related guides
Cheapest GLP-1 in 2026 →
Side-by-side cash-pay prices for every FDA-approved GLP-1, ranked by $/lb lost.
Full GLP-1 cost comparison chart →
Every drug, every channel, every dollar in one table.
GLP-1 savings cards compared →
Wegovy, Zepbound, Mounjaro, Ozempic - eligibility and the government-insurance trap.
GLP-1 prior authorization →
Insurance approval playbook: what they want, common denials, how to appeal.
GLP-1 telehealth providers compared →
Hims, Ro, Found, LifeMD, Lemonaid, GoodRx Care - pricing, drugs, speed.
GLP-1 vs bariatric surgery cost →
10-year total-cost comparison: medication vs gastric sleeve vs bypass.